ncRNA name | mmu-miR-497a-5p |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Mus musculus |
Tissues/Cell_line | mouse epithelial cell line MS1; whole eyes |
Methods | transfection, luciferase reporter assay, FFA, ELISA, qRT-PCR, immunohistochemistry, Western blot |
Expression pattern | up-regulated |
Functional description | Metformin may inhibit the VEGF-A protein translation through inducing a VEGF-A-targeting microRNA, microRNA-497a-5p, resulting in reduced retina neovascularization. |
PubMed ID | 29312507 |
Year | 2017 |
Title | Metformin inhibits development of diabetic retinopathy through microRNA-497a-5p. |
Drug-related ncRNA | YES (Metformin) |
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